Sleep isn’t just a nice rest for your grey matter. Far from it: It’s when your brain goes into housekeeping mode and cerebrospinal fluid mop away metabolic wastes that have accumulated during the day.

This discovery, in the US lab of neuroscientist Dr Maiken Nedergaard, may explain why lack of sleep has such a profound effect on our brains, making us forgetful, unable to concentrate, grumpy, accident prone, and clumsy. It may also open the door to preventing neurodegenerative illnesses linked to the accumulation of waste products in the brain, like the amyloid deposits associated with Alzheimer’s disease.

The scariest news: If you deprive your brain of adequate rest long or often enough, it may never fully bounce back. “We used to think your brain could recover with extra sleep,” says sleep expert Dr Sigrid Veasey. (Who hasn’t slept in on weekends to try to catch up?)

But last spring, Dr Veasey found that extended sleep deprivation can lead to a permanent loss of cells involved in functions like alertness, attention, and recall. What’s more, while everyone’s brain loses volume over time, the shrinkage happens faster in people who have trouble sleeping than in those who are better rested, a recent European study found. The brain areas in which cells are lost are the ones that regulate decision-making, emotion, memory, and learning. “We can no longer think of sleep as a luxury,” Dr Veasey says. Experts recommend seven to nine hours a night. Read on for the surprising things blocking you from getting shut-eye - and how to conquer them.

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